Polycomb complexes in X chromosome inactivation
نویسندگان
چکیده
منابع مشابه
Polycomb complexes in X chromosome inactivation
Identifying the critical RNA binding proteins (RBPs) that elicit Xist mediated silencing has been a key goal in X inactivation research. Early studies implicated the Polycomb proteins, a family of factors linked to one of two major multiprotein complexes, PRC1 and PRC2 (Wang 2001 Nat. Genet.28, 371-375 (doi:10.1038/ng574); Silva 2003 Dev. Cell4, 481-495 (doi:10.1016/S1534-5807(03)00068-6); de N...
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Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...
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Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long noncoding RNAs. Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression. PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of oth...
متن کاملx chromosome inactivation in opioid addicted women
introduction: x chromosome inactivation (xci) is a process during which one of the two x chromosomes in female human is silenced leading to equal gene expression with males who have only one x chromosome. here we have investigated xci ratio in females with opioid addiction to see whether xci skewness in women could be a risk factor for opioid addiction. methods: 30 adult females meeting dsm iv ...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2017
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2017.0021